Currently you can press "R" to roll/randomize but you cannot remap this in the settings for some reason. Not a huge deal, but it would be nice for RPG to remap to a mouse button if you use it a lot.
The bigger issue, again for RPG users, is that when using PDFs, you cannot press a button to "popout" the PDF. You have to right click and select popout. Similarly you cannot press a button to close the popout. I use the "alt" key to zoom in a lot, and would love to have another button similar to that only a toggle to press and popout the pdf, let me flip through a few pages and then press it again to close the popout pdf.
All this said, there should also be lua commands for these as well.